期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 9, 期 12, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a021642
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资金
- ESPA from the Greek General Secretariat of Research and Development/Ministerium of Education [PENED 01ED371, EPAN YB-22, PEP ATT-39, ESPA 09SYN-21-965]
- Excellence II/ARISTEIA II [5342]
- U.S. National Institutes of Health [RO1 AR39617]
- COST (Cooperation of Science and Technology) BM (Biomedicine and Molecular Sciences) [1002]
- NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek)
- ISAO (Internationale Stichting Alzheimer Onderzoek)
Type III intermediate filament (IF) proteins assemble into cytoplasmic homopolymeric and heteropolymeric filaments with other type III and some type IV IFs. These highly dynamic structures form an integral component of the cytoskeleton of muscle, brain, and mesenchymal cells. Here, we review the current ideas on the role of type III IFs in health and disease. It turns out that they not only offer resilience to mechanical strains, but, most importantly, they facilitate very efficiently the integration of cell structure and function, thus providing the necessary scaffolds for optimal cellular responses upon biochemical stresses and protecting against cell death, disease, and aging.
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