期刊
CURRENT OBESITY REPORTS
卷 6, 期 3, 页码 253-265出版社
SPRINGER
DOI: 10.1007/s13679-017-0276-5
关键词
Bariatric surgery; Gastric banding; Sleeve gastrectomy; Roux-en-Y gastric bypass; Gut hormones; Gastrin; GLP-1; GLP-2; PYY; Ghrelin; CCK; GIP; Oxyntomodulin; Secretin; VIP; PP; Insulin; Glucagon; Somatostatin; Obestatin; Gustducin; FGF19; FGF21
资金
- National Institute for Health Research [CL-2013-21-002] Funding Source: researchfish
In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized. Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.
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