期刊
ALZHEIMERS & DEMENTIA
卷 11, 期 3, 页码 310-320出版社
WILEY
DOI: 10.1016/j.jalz.2013.10.005
关键词
Incidence of dementia; Alzheimer's disease; Gender; Mortality; Cardiovascular risk profile; Selective survival; Cohort/population-based cohort; Prevention
资金
- National Heart, Lung, and Blood Institute [N01-HC-25195]
- National Institute of Neurological Disorders and Stroke [NS17950]
- National Heart, Lung, and Blood Association [HL93029, U01HL 096917]
- National Institute of Aging [AG08122, AG16495, AG033193, AG031287]
- Fondation Plan Alzheimer
Background: Gender-specific risks for dementia and Alzheimer's disease (AD) starting in rnidlife remain largely unknown. Methods: Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]). Results: Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65. Conclusion: Selective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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