期刊
CELL TRANSPLANTATION
卷 26, 期 9, 页码 1520-1529出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0963689717721201
关键词
aging; bone marrow (BM); mesenchymal stromal cells (MSCs); in vitro; in vivo
资金
- Leeds Institute of Rheumatic and Musculoskeletal Medicine
- Arbeitsgemeinschaft fur Osteosynthesefragen (AO) foundation
- Innovative Medicines Initiative (IMI) [115142-2]
Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and fitness of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs age similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据