期刊
CHEMOSENSORS
卷 5, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/chemosensors5030025
关键词
glutamic acid-modified screen-printed electrode; voltammetry; electropolymerization; electrografting; hydrochlorothiazide determination
资金
- Generalitat of Catalonia (Chile) [2014SGR269]
- FONDECYT (Chile) [1170352]
- [21130071]
This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of mol L-1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness.
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