期刊
ACS NANO
卷 11, 期 9, 页码 9239-9248出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b04461
关键词
Au-Fe2C Janus nanoparticles; magnetic resonance imaging; multispectral photoacoustic tomography; computed tomography; photothermal therapy
类别
资金
- National Natural Science Foundation of China [51672010, 51631001, 81421004, 51590882, 51602285, 21575161]
- Research Fellowship for International Young Scientists of the National Natural Science Foundation of China [51550110502]
- Interdisciplinary Project of Beijing New Star Plan of Science and Technology
- State Key Project of Research and Development of China [2017YFA0206301, 2016YFA0200102]
- Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences [NSKF201607]
Imaging-guided photothermal therapy (PTT) by combination of imaging and PTT has been emerging as a promising therapeutic method for precision therapy. However, the development of multicomponent nanoplatforms with stable structures for both PTT and multiple-model imaging remains a great challenge. Herein, we synthesized monodisperse Au-Fe2C Janus nanoparticles (JNPs) of 12 nm, which are multifunctional entities for cancer theranostics. Due to the br,oad absorption in the near-infrared range, Au-Fe2C JNPs showed a significant photothermal effect with a 30.2% calculated photothermal transduction efficiency under 808 nm laser irradiation in vitro. Owing to their excellent optical and magnetic properties, Au-Fe2C JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/multispectral photoacoustic tomography (MSOT)/computed tomography (CT) both in vitro and in vivo. We found that Au-Fe2C JNPs conjugated with the affibody (Au-Fe2C Z(HER2,342)) have more accumulation and deeper penetration in tumor sites than nontargeting JNPs (Au-Fe2C PEG) in vivo. Meanwhile, our results verified that Au-Fe2C-Z(HER2,342) JNPs can selectively target tumor cells with low cytotoxicity and ablate tumor tissues effectively in a mouse model. In summary, monodisperse Au-Fe2C JNPs, used as a multifunctional nanoplatform, allow the combination of multiple-model imaging techniques and high therapeutic efficacy and have great potential for precision theranostic nanomedicines.
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