期刊
EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY
卷 7, 期 3, 页码 168-175出版社
AKADEMIAI KIADO ZRT
DOI: 10.1556/1886.2017.00014
关键词
children; diarrheagenic Escherichia coli; antibiotic; phenotype; MDR; PCR; Burkina Faso
类别
资金
- Campus France and Reseau de Recherche sur les Maladies Enteriques a potentiel epidemique en Afrique de l'Ouest (REMENTA)/Programme d'Appui a la Recherche en Reseau en Afrique (PARRAF)
The emergence and persistence of multidrug-resistant (MDR) diarrheagenic Escherichia coli (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in Centre Medical avec Antenne Chirurgicale (CMA) Paul VI and CMA of Schiphra. DEC were isolated and identified by standard microbiological methods and polymerase chain reaction (PCR) method was used to further characterize them. Antimicrobial susceptibility testing was done based on the disk diffusion method. DEC isolates were high resistant to tetracycline (83.9%), amoxicillin (77.4%), amoxicillin clavulanic acid (77.4%), piperacillin (64.5%), and colistin sulfate (61.3%). The most resistant phenotype represented was the extended spectrum beta-lactamase (ESBL) phenotype (67.7%). Aminoglycosides were 100% active on enteroinvasive E. coli (EIEC) and enterohemorrhagic E. coli (EHEC). All the DEC isolates exhibited absolute (100%) sensitivity to ciprofloxacin. Monitoring and studying the resistance profile of DEC to antibiotics are necessary to guide probabilistic antibiotic therapy, especially in pediatric patients.
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