期刊
INTERNATIONAL JOURNAL OF BIOMATHEMATICS
卷 10, 期 4, 页码 -出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793524517500504
关键词
Thermostability; thermophilic protein; fragment; support vector machine.
资金
- Project of Youth Scientific Research Foundation of Shandong Academy of Agricultural Sciences [2014QNM30]
- Transgenic New Variety Cultivation [2011ZX08003- 006]
- Applied Basic Research Program of Sichuan Province [LZ-LY-45]
- Scientific Research Foundation of the Education Department of Sichuan Province [11ZB122]
Improving thermostability of an enzyme can accelerate the relevant chemical reaction. Thus, the analysis and prediction of thermophilic proteins are conducive to protein engineering and enzyme design. In this study, a novel method based on two-step discrimination was proposed to distinguish between thermophilic and non-thermophilic proteins. The model was rigorously benchmarked on an objective dataset including 915 thermophilic proteins and 793 non-thermophilic proteins. Results showed that the overall accuracy of our method is 94.44% in 5-fold cross-validation, which is higher than those of other published methods. We believe that the two-step discriminated strategy will become a promising method in the relevant field of protein bioinformatics.
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