期刊
JOURNAL OF FUNCTIONAL FOODS
卷 35, 期 -, 页码 384-390出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.05.052
关键词
Barley leaf; Intestinal immune system; Immunoglobulin A; Peyer's patch; Polysaccharide
资金
- Korean Food Research Institute
- Korea Foundation for Cancer Research [KFCR-2014-002]
Four polysaccharide fractions were prepared from barley leaves and then in vitro intestinal immunostimulatory activity was compared. Among fractions, high molecular weight fraction prepared by enzyme extraction, namely BLE-P, showed the potent in activating bone marrow cell proliferation through Peyer's patch (PP), and in stimulating cytokine production in in vitro. By performing monosaccharide composition analysis, BLE-P was identified as a mixture of hemicellulosic glucuronoarabinoxylan and pectic rhamnogalacturonan I accounting for above 80%. Subsequently, BLE-P was orally administered to mice for 20 days to investigate the effect on the in vivo intestinal immunostimulatory activity. BLE-P administration not only augmented the production of immunoglobulin A (IgA), but also increased the levels of IgA-related cytokines, such as transforming growth factor-beta and interleukin-10. These results suggest that BLE-P is most likely to facilitate the production of IgA via induction of various IgA-producing cytokines in small intestinal immune system. (C) 2017 Elsevier Ltd. All rights reserved.
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