期刊
JOURNAL OF FUNCTIONAL FOODS
卷 37, 期 -, 页码 685-698出版社
ELSEVIER
DOI: 10.1016/j.jff.2017.08.038
关键词
AHR; ICZ; Indole-3-carbinol; Broccoli; Intestinal homeostasis; Ah receptor
资金
- Agriculture and Food Research Initiative Competitive from the USDA National Institute of Food and Agriculture [2014-06624]
- National Institutes of Health [ES004869, ES019964]
Consumption of broccoli mediates numerous chemo-protective benefits through the intake of phyto-chemicals, some of which modulate aryl hydrocarbon receptor (AHR) activity. Whether AHR activation is a critical aspect of the therapeutic potential of dietary broccoli is not known. Here we administered iso-caloric diets, with or without supplementation of whole broccoli (15% w/w), to congenic mice expressing the high-affinity Ahr(b/b) or low-affinity Ahr(d/d) alleles, for 24 days and examined the effects on AHR activity, intestinal microbial community structure, inflammatory status, and response to chemically induced colitis. Cecal microbial community structure and metabolic potential were segregated according to host dietary and AHR status. Dietary broccoli associated with heightened intestinal AHR activity, decreased microbial abundance of the family Erysipelotrichaceae, and attenuation of colitis. In summary, broccoli consumption elicited an enhanced response in ligand-sensitive Ahr(b/b) mice, demonstrating that in part the beneficial aspects of dietary broccoli upon intestinal health are associated with heightened AHR activity. (c) 2017 Elsevier Ltd. All rights reserved.
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