期刊
JOURNAL OF FUNCTIONAL FOODS
卷 37, 期 -, 页码 363-372出版社
ELSEVIER
DOI: 10.1016/j.jff.2017.07.054
关键词
Eryngium maritimum; Phytochemical; Antioxidant; Hepatoprotective; Nephroptotective; Antifibrotic
The present work was undertaken to investigate the protective effects of Eryngium maritimum seeds extract (MEE) against CCl4 and cisplatin induced toxicity in rats. The levels of total phenolics and flavonoids were ca. 20 mg GAE/g and ca. 19 mg QE/g, respectively. Using HPLC twenty-one molecules were identified. MEE showed important in vitro antioxidant activities. Results demonstrated that MEEtreatment restored the increased activities of AST, ALT, LDH and ALP and the high levels of serum creatinine, urea and uric acid levels induced by CCl4 and cisplatin treatment. Moreover, MEE presented important in vivo antioxidant activities; increased the activities of CAT, SOD and GPx and decreased the TBARS and protein carbonyl contents. The histopathological studies suggested that MEE clearly alleviated the degree of tissues fibrosis. The obtained results highlighted the potential use of E. maritimum as a source of bioactive compounds with hepatoprotective and nephroprotective advantages. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据