期刊
JOURNAL OF FUNCTIONAL FOODS
卷 39, 期 -, 页码 123-132出版社
ELSEVIER
DOI: 10.1016/j.jff.2017.09.061
关键词
Hypoglycemic; beta-ecdysterone; GLUT4; Akt; IRS-1; IR beta
资金
- National Natural Science Foundation of China [81573561, 81774000]
- Hubei Key science and technology innovation project [2016ACA138]
- Hubei Provincial Training Programs of Innovation and Entrepreneurship for Undergraduates [SCX15025]
Our present study investigated the anti-diabetic activity and potential mechanism of O-ecdysterone (beta-EC) derived from Cyanotis arachnoidea. In vitro, beta-EC exhibited a promising effect on increasing GLUT4 translocation by 1.6 folds and glucose uptake by 1.75 folds in L6 cells. In vivo, KK-Ay mice's body weight, blood glucose levels and other related blood-lipid indexes can be significantly reduced with beta-EC treatment. For the mechanism study, we have found that beta-EC exhibited a significant protective effect on insulin resistance (IR) in L6 and HepG2 cells through increasing expressions of IR beta, p-Akt, p-IRS-1 and increasing the expressions of GLUT4 and GLUT2. The phosphorylation of Akt, IRS-1 and the expression of itzp, GLUT4 and GLUT2 in the liver and skeletal muscle in KK-Ay mice were also significantly ameliorated after 4-weeks treatment with beta-EC. According to our present findings, we could conclude that beta-EC possessed the potential anti-diabetic effects through activating IRS-1/AKT/GLUT4 and IRS-1/AICT/GLUT2 pathways. (C) 2017 Elsevier Ltd. All rights reserved.
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