期刊
COLLOID AND POLYMER SCIENCE
卷 295, 期 9, 页码 1455-1461出版社
SPRINGER
DOI: 10.1007/s00396-017-4113-x
关键词
Boron neutron capture therapy; PEGylation; Liposomes; Drug delivery; Decaborane; Biodistribution
资金
- Program for Development of Strategic Research Center in Private Universities by MEXT
Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of B-10 into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40-43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 mu g/g of tissue and over 5 at 8-24 h, respectively. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 mu g/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral B-10 amount without replacing the B-11 with B-10.
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