期刊
FEMS MICROBIOLOGY LETTERS
卷 364, 期 18, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnx176
关键词
cyanobacteria; carbon fixation; carboxysome; modularity; protein domains; synthetic biology
类别
资金
- United States Department of Energy, Basic Energy Sciences [DE-FG02-91ER20021]
- Michigan State University Foundation [14-SPG-Fulll-2962]
- United States Department of Energy, Bioenergy Technologies Office (Producing Algae for Coproducts and Energy project) [DE-EE0007089/0002]
The carboxysome is a bacterial microcompartment encapsulating the enzymes carbonic anhydrase and ribulose-1,5-bisphosphate carboxylase/oxygenase. As the site of CO2 fixation, it serves an essential role in the carbon dioxide concentrating mechanism of many chemoautotrophs and all cyanobacteria. Carboxysomes and other bacterial microcompartments self-assemble through specific protein-protein interactions that are typically mediated by conserved protein domains. In this review, we frame our current understanding of carboxysomes in the context of their component protein domains with their inherent function as the 'building blocks' of carboxysomes. These building blocks are organized in genetic modules (conserved chromosomal loci) that encode for carboxysomes and ancillary proteins essential for the integration of the organelle with the rest of cellular metabolism. This conceptual framework provides the foundation for 'plug-and-play' engineering of carboxysomes as CO2 fixation modules in a variety of biotechnological applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据