期刊
MEDCHEMCOMM
卷 8, 期 1, 页码 198-201出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00493h
关键词
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资金
- National Natural Science Foundation of China [31471086]
- Fundamental Research Funds for the Central Universities of China [3102015ZY084]
- Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University [Z2016197]
A high-throughput assay was developed to identify inhibitors of cystathionine beta-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 mu M.
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