期刊
BIOANALYSIS
卷 9, 期 21, 页码 1655-1666出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2017-0140
关键词
benzoylecgonine; breast milk; cocaine; GC/MS; magnetic carbon nanotubes
资金
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Ministerio da Saude (MS)
Aim: The increasing use of cocaine (COC) during breastfeeding has led to growing concern about exposure of infants. Therefore, to study this exposure, a new method to analyze COC and benzoylecgonine in breast milk was developed. Methodology: A new extraction method was used for the first time to analyze COC and its major metabolite, benzoylecgonine, in breast milk using magnetic carbon nanotubes partially doped with nitrogen. Results: The calibration curves were linear in the range 5.0-180.0 ng ml(-1). The limit of quantification was 5.0 ng ml(-1). Coefficients of variation were between 3.2 and 13.9%. Recovery was between 89.6 and 99.2%. Conclusion: The proposed method is simple, efficient and suitable to determine analytes in breast milk.
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