期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 157, 期 -, 页码 199-206出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.05.079
关键词
Silver nanoparticles; Mesoporous silica; Janus; Cetyltrimethylammonium bromide; Synergistic antibacterial activity
资金
- National Natural Science Foundation of China [61535010, 81601609]
- Key Research Program of the Chinese Academy of Sciences [KFZD-SW-204]
- Natural Science Foundation of Jiangsu Province [BE2015601]
- Science and Technology Department of Suzhou City [SS201539, ZXY201434]
In this study, we exploited a one-pot method to fabricate cetyltrimethylammonium bromide (CTAB)-loaded Janus silver mesoporous silica nanoparticles (Janus Ag-MSNs@CTAB). These bullet-like nanoparticles had a silver head (80 nm in diameter) attached to a mesoporous silica stick (200-300 nm in length). The CTAB-loaded nanobullets exhibited a marked affinity for the bacterial cell surface and the simultaneously sustained release behavior of CTAB and silver ions. The minimum inhibitory concentrations (MIC) of Janus Ag-MSNs@CTAB were determined to be 10 mu g@mL and 20 mu g/mL for E. coli and S. Aureus, respectively. Importantly, Janus Ag-MSNs@CTAB provided a single-particle nanoplatform with a synergistic effect against both Gram-positive and Gram-negative bacteria. A thorough investigation indicated that CTAB induces a dramatic loss of bacterial membrane integrity, which facilitated the internalization of silver. This report described an efficient and convenient method of synthesizing Janus silver mesoporous silica nanoparticles, and these nanobullets show promising potential in biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.
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