4.3 Article

Circuit Mechanisms Governing Local vs. Global Motion Processing in Mouse Visual Cortex

期刊

FRONTIERS IN NEURAL CIRCUITS
卷 11, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2017.00109

关键词

visual cortex; direction selectivity; local motion; global motion; pattern cell; component cell

资金

  1. Lundbeckfonden
  2. European Research Council [638730]
  3. Novo Nordisk Foundation
  4. European Research Council (ERC) [638730] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

A withstanding question in neuroscience is how neural circuits encode representations and perceptions of the external world. A particularly well-defined visual computation is the representation of global object motion by pattern direction-selective (PDS) cells from convergence of motion of local components represented by component direction-selective (CDS) cells. However, how PDS and CDS cells develop their distinct response properties is still unresolved. The visual cortex of the mouse is an attractive model for experimentally solving this issue due to the large molecular and genetic toolbox available. Although mouse visual cortex lacks the highly ordered orientation columns of primates, it is organized in functional sub-networks and contains striate-and extrastriate areas like its primate counterparts. In this Perspective article, we provide an overview of the experimental and theoretical literature on global motion processing based on works in primates and mice. Lastly, we propose what types of experiments could illuminate what circuit mechanisms are governing cortical global visual motion processing. We propose that PDS cells in mouse visual cortex appear as the perfect arena for delineating and solving how individual sensory features extracted by neural circuits in peripheral brain areas are integrated to build our rich cohesive sensory experiences.

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