期刊
FRONTIERS IN NEURAL CIRCUITS
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2017.00051
关键词
petabyte; terabyte; massive imageset; neuron reconstruction; software platform
资金
- National Basic Research Program of China [2015CB755602]
- Science Fund for Creative Research Group of China [61421064]
- National Natural Science Foundation of China [91432105, 91432116, 91232000]
- National Key Scientific Instrument and Equipment Development Program of China [2012YQ030260]
- Wuhan National Laboratory for Optoelectronics
- Seed Foundation of Huazhong University of Science and Technology [2015XJGH004]
Three-dimensional imaging of whole mammalian brains at single-neuron resolution has generated terabyte (TB)-and even petabyte (PB)-sized datasets. Due to their size, processing these massive image datasets can be hindered by the computer hardware and software typically found in biological laboratories. To fill this gap, we have developed an efficient platform named TDat, which adopts a novel data reformatting strategy by reading cuboid data and employing parallel computing. In data reformatting, TDat is more efficient than any other software. In data accessing, we adopted parallelization to fully explore the capability for data transmission in computers. We applied TDat in large-volume data rigid registration and neuron tracing in whole-brain data with single-neuron resolution, which has never been demonstrated in other studies. We also showed its compatibility with various computing platforms, image processing software and imaging systems.
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