期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2017.00164
关键词
IPSC; schizophrenia; variability; disease models; genetics; psychiatric diseases; statistical power; stem cells
资金
- The Netherlands Organization for Scientific Research [NWO VICI 453-14-005]
- ZonMw VIDI research grant [91712343]
- E-Rare Joint Call Project [9003037601]
Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.
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