期刊
ANNALS OF NEUROLOGY
卷 82, 期 2, 页码 278-287出版社
WILEY
DOI: 10.1002/ana.25003
关键词
-
资金
- Action Medical Research [SP4646]
- Engineering and Physical Sciences Research Council [EP/M001393/1]
- James Lewis Foundation (via Great Ormond Street Hospital Children's Charity)
- Child Health Research Appeal Trust
- University College London Overseas Research Scholarship
- University College London IMPACT
- National Institute for Health Research Biomedical Research funding
- Swiss National Science Foundation [SNF 141165]
- Gertrude von Meissner Foundation
- Center for Biomedical Imaging of Geneva and Lausanne, Switzerland
- National Institute of Health Research Great Ormond Street Hospital Biomedical Research Centre
- Action Medical Research [1830] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/M001393/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0515-10073] Funding Source: researchfish
- EPSRC [EP/M001393/1] Funding Source: UKRI
Objective: Surgical treatment in epilepsy is effective if the epileptogenic zone (EZ) can be correctly localized and characterized. Here we use simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) data to derive EEG-fMRI and electrical source imaging (ESI) maps. Their yield and their individual and combined ability to (1) localize the EZ and (2) predict seizure outcome were then evaluated. Methods: Fifty-three children with drug-resistant epilepsy underwent EEG-fMRI. Interictal discharges were mapped using both EEG-fMRI hemodynamic responses and ESI. A single localization was derived from each individual test (EEG-fMRI global maxima [GM]/ESI maximum) and from the combination of both maps (EEG-fMRI/ESI spatial intersection). To determine the localization accuracy and its predictive performance, the individual and combined test localizations were compared to the presumed EZ and to the postsurgical outcome. Results: Fifty-two of 53 patients had significant maps: 47 of 53 for EEG-fMRI, 44 of 53 for ESI, and 34 of 53 for both. The EZ was well characterized in 29 patients; 26 had an EEG-fMRI GM localization that was correct in 11, 22 patients had ESI localization that was correct in 17, and 12 patients had combined EEG-fMRI and ESI that was correct in 11. Seizure outcome following resection was correctly predicted by EEG-fMRI GM in 8 of 20 patients, and by the ESI maximum in 13 of 16. The combined EEG-fMRI/ESI region entirely predicted outcome in 9 of 9 patients, including 3 with no lesion visible on MRI. Interpretation: EEG-fMRI combined with ESI provides a simple unbiased localization that may predict surgery better than each individual test, including in MRI-negative patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据