期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2017.00330
关键词
PDK1; Akt; mTOR; neuron loss; apoptosis; learning and memory
资金
- National Basic Research Program of Ministry of Science and Technology of China [2014CB942804]
- National Natural Science Foundation of China [31271123, 81230026, 81630028]
- National Key Research and Development Program of China [2016YFC1300504]
- Key Research and Development Program of Nanjing Municipal Health Bureau [ZKX16031]
- Fundamental Research Funds for Central Universities [14380012, 14380322]
- Jiangsu Provincial Key Medical Discipline [ZDXKA2016020]
- Alzheimer's Research in United Kingdom
- MRC [UKDRI-4004] Funding Source: UKRI
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice. We demonstrate that PDK1 cKO mice display striking neuron loss and increased apoptosis. We report that PDK1 cKO mice exhibit deficits on several behavioral tasks. Moreover, PDK1 cKO mice show decreased activities for Akt and mTOR. These results highlight an essential role of endogenous PDK1 in the maintenance of neuronal survival during cortical development.
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