期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 45, 期 -, 页码 162-168出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.05.012
关键词
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资金
- Swiss SystemsX initiative
- Swiss National Science Foundation
- European Research Council
- Kanton Basel-Stadt
Brain development and function are governed by tightly controlled gene expression programs. Transcriptional repertoires in neurons are highly specific to developmental stage, neuronal cell type and can undergo rapid changes upon neuronal stimulation. Dedicated molecular mechanisms are required to achieve such fine-tuned regulation. In addition to transcriptional programs, post-transcriptional processes and notably alternative splicing substantially contribute to the elaboration of neuronal gene expression. While alternative splicing has been viewed primarily as a means for expanding proteome diversity, it emerges to also be a major regulator of transcript levels and dynamics. In this review we will describe some of the principal alternative splicing-linked mechanisms that control neuronal transcriptomes and discuss their implications for the central nervous system.
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