期刊
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
卷 25, 期 1, 页码 49-54出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MED.0000000000000377
关键词
breast development; dioxins; endocrine disrupting compounds; genital staging; menarche; pesticides; puberty; sexual maturation
资金
- US EPA [R82943701]
- NIEHS [ES-14370]
- [ES00002]
- [ES017117]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES000002, R01ES014370, R03ES017117] Funding Source: NIH RePORTER
Purpose of review The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. Recent findings In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty. Summary The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies.
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