期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 89, 期 1, 页码 52-57出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2017.06.014
关键词
Bacterial; Identification; Susceptibility; Automated; Resistance
资金
- ALSAC, Memphis, TN
Identification (ID) and antimicrobial susceptibility testing (AST) remain rate limiting steps in producing actionable data for clinical care of bloodstream infections. Rapid, automated phenotypic ID and AST by fluorescent in situ hybridization and automated microscopy were used to characterize blood stream infections in a predominantly pediatric oncology patient population. Results were compared to standard of care (SOC) phenotypic methods. The Accelerate Pheno System (AXDX) had a sensitivity of 91.2% and an accuracy of 100% to the genus level for identification, and an overall categorical agreement 912-91.8% for susceptibility, depending on the breakpoints used. The AXDX required a mean time of 1.4 hours for identification and 6.6 hours for susceptibility testing compared to SOC, requiring 32.5 and 46.7 hours, respectively. Identification and susceptibility by rapid phenotypic methods shows a high degree of accuracy; the marked reduction in time to results may have significant implications for patient care. (C) 2017 Elsevier Inc. All rights reserved.
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