Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells

Telomerase is a key regulator in cell metabolism, tissue renewal, and organismal lifespan. Here we develop a simple strategy to modulate cellular telomerase activity, and further control cell fate based on Mg2+- and Zn2+-activated DNAzymes in living cells. Through modulation of telomerase activity, we can regulate cell behavior, including cell migration, cell differentiation, cell senescence, and cell cycle. Our work provides a new way to modulate telomerase activity in living cells by using DNAzymes.