期刊
CHEMICAL SCIENCE
卷 8, 期 5, 页码 3489-3493出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc00251c
关键词
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资金
- NSFC [81573383, 21390402, 81301268]
- NSFHP [2014CFB704]
- ISTCPC [2015DFA30440, 2014CFB30020]
- Major Project of Technology Innovation Program of Hubei Province [2016ACA126]
- Applied Basic Research Programs of Scientific and Technologic Council of Suzhou [SYG201521]
- Natural Science Foundation of Jiangsu Province [BK20160387]
- Beijing Nova Plan Z [131107000413063]
- Fundamental Research Funds for the Central Universities
Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY approximate to 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and image-guided surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II image-guided sentinel lymph node (SLN) surgery.
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