期刊
CHEMICAL SCIENCE
卷 8, 期 9, 页码 5845-5888出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc01045a
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资金
- NSF [CHE-1265687]
- NIH Grant from the National Institute on Minority Health and Health Disparities [G12MD007603]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1265687] Funding Source: National Science Foundation
Cross-dehydrogenative coupling (CDC) is a process in which, typically, a C-C bond is formed at the expense of two C-H bonds, either catalyzed by metals or other organic compounds, or via uncatalyzed processes. In this perspective, we present various modes of C-H bond-activation at sp(3) centers adjacent to ether oxygen atoms, followed by C-C bond formation with aromatic systems as well as with heteroaromatic systems. C-N bond-formation with NH-containing heteroaromatics, leading to hemiaminal ethers, is also an event that can occur analogously to C-C bond formation, but at the expense of C-H and N-H bonds. A large variety of hemiaminal ether-forming reactions have recently appeared in the literature and this perspective also includes this complementary chemistry. In addition, the participation of C-H bonds in alcohols in such processes is also described. Facile access to a wide range of compounds can be attained through these processes, rendering such reactions useful for synthetic applications via C-sp3 bond activations.
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