期刊
CHEMICAL SCIENCE
卷 8, 期 9, 页码 6650-6655出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc01750b
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology [22105002]
- Japan Science and Technology Agency [JPMJCR12YS]
- Grants-in-Aid for Scientific Research [22105002] Funding Source: KAKEN
The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBut involves C-H/N-H oxidative annulation to give 1(2H)-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBut. The reaction shows a high functional group compatibility. The reaction with unsymmetrical alkynes, such as 1-arylalkynes, gives the corresponding 1(2H)-isoquinolinones with a high level of regioselectivity. This discovery would lead to the development of Nicatalyzed chelation-assisted C-H functionalization reactions without the need for a specific chelation system.
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