4.8 Article

Visualising the membrane viscosity of porcine eye lens cells using molecular rotors

期刊

CHEMICAL SCIENCE
卷 8, 期 5, 页码 3523-3528

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc05369f

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资金

  1. EPSRC [EP/I003983/1]
  2. EPSRC
  3. RSC
  4. Russian Scientific Foundation [14-14-00056]
  5. EPSRC [EP/K030760/1, EP/I003983/1] Funding Source: UKRI
  6. Engineering and Physical Sciences Research Council [EP/I003983/1, 1372083, EP/K030760/1] Funding Source: researchfish

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The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive 'molecular rotors' to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.

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