期刊
CHEMICAL SCIENCE
卷 8, 期 7, 页码 5196-5200出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc00952f
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资金
- National University of Singapore [R-143-000-599-112]
- National Natural Science Foundation of China [21672158]
- KFUPM-NUS Collaborative Fund support [NUS15103, R-143-004-617-597]
Enantioselective intramolecular [3 + 2] annulation of chalcones bearing an allene moiety has been successfully developed. The reaction was effectively promoted by amino acid-derived phosphines, in combination with achiral Bronsted acids. Dihydrocoumarin architectures were constructed in high yields and with excellent enantiomeric excesses. Theoretical studies via DFT calculations revealed that the hydrogen bonding network induced by achiral Bronsted acids/chiral phosphines could more efficiently distinguish between two enantioselective pathways, thus leading to enhanced enantioselectivity.
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