The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease

Cardiovascular disease is a common co-morbidity found with obesity-linked type 2 diabetes. Current pharmaceuticals for these two diseases treat each of them separately. Yet, diabetes and cardiovascular disease share molecular signaling pathways that are increasingly being understood to contribute to disease pathophysiology, particularly in pre-clinical models. This review will focus on one such signaling pathway: that mediated by the G protein-coupled receptor, Prostaglandin E-2 Receptor 3 (EP3), and its associated G protein in the insulin-secreting beta-cell and potentially the platelet, G(z). The EP3/G(z) signaling axis may hold promise as a dual target for type 2 diabetes and cardiovascular disease.