期刊
CHEMICAL SCIENCE
卷 8, 期 10, 页码 7031-7037出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc03189k
关键词
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资金
- Seoul National University Foreign Faculty Fund
- New Faculty Resettlement Fund
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A2A2A01002895, 2013R1A1A2057837, 2014-011165]
- BK21Plus Program, Ministry of Education
- National Research Foundation of Korea (NRF) - Korean government (MSIP) (Center for New Directions in Organic Synthesis)
- Novartis
- National Research Foundation of Korea [2012R1A2A2A01002895, 2013R1A1A2057837] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Herein we report a rationally designed, serial point-to-axial and axial-to-point stereoinduction and its integration into multi-step and target-oriented organic synthesis. In this proof-of-concept study, the configurational stability of several carefully designed atropisomeric intermediates and the fidelity of their unconventional stereoinductions were systematically investigated. The highly functionalized prepared synthetic intermediate was further applied in a novel chemical method to access the morphinans and it is potentially applicable to other structurally related alkaloids.
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