期刊
CHEMICAL SCIENCE
卷 8, 期 6, 页码 4619-4625出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc01109a
关键词
-
资金
- Spanish Ministry of Economy and Competitiveness [CTQ2016-80844-R, BES-2013-065642, BIO2014-61838-EXP, BIO2015-69887-R]
- Department of Industry of the Basque Country (grant ETORTEK)
- MICINN of Spain [RYC-2011-07787]
- MC CIG fellowship UCnanomat4iPACT grant [321791]
- Ikerbasque
- European COST Actions [CM1105, CM103, CM1403]
Encouraging developments demonstrate that few transition metal and organometallic catalysts can operate in a bioorthogonal fashion and promote non-natural chemistry in living systems by minimizing undesired side reactions with cellular components. These catalytic processes have potential for applications in medicinal chemistry and chemical biology. However, the stringent conditions of the cell environment severely limit the number of accessible metal catalysts and exogenous reactions. Herein, we report an unorthodox approach and a new type of bioorthogonal catalytic reaction, in which a metal complex is an unconventional substrate and an exogenous biological molecule acts as a catalyst. In this reaction, riboflavin photocatalytically converts a Pt-IV prodrug into cisplatin within the biological environment. Due to the catalytic activity of riboflavin, cisplatin-like apoptosis is induced in cancer cells under extremely low doses of light, potentially preventing systemic off-target reactions. Photocatalytic and bioorthogonal turnover of Pt-IV into Pt-II species is an attractive strategy to amplify the antineoplastic action of metal-based chemotherapeutics with spatio-temporal control.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据