期刊
CHEMICAL SCIENCE
卷 8, 期 2, 页码 1436-1441出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc03712g
关键词
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资金
- European Union under a Marie Curie International Incoming Fellowship [PIIF-GA-2013-625471]
- EPSRC
- University of Sheffield
We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted nitrile products. The nitrile was treated with TMPMgCl and the resulting anion, an asymmetric alpha cyano Grignard species, was found to be configurationally stable at low temperature for a short time ( half-life several minutes at -104 degrees C).
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