期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 491, 期 1, 页码 178-182出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.07.072
关键词
ARID1A; SWI/SNF chromatin remodeling complex; IncRNA; Hepatocellular carcinoma; MVIH
资金
- National Natural Science Foundation of China [81472621, 81402329, 81672772]
- Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University [YG2014MS35, YG2015QN43, YG2016MS43]
- Morning Star Excellent Young Researcher Program of Shanghai Jiao Tong University [AF4150022]
- Shanghai Pujiang Program [14PJ1405500]
ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer. LncRNAs, a type of non-coding RNAs longer than 200 nucleotides, have been reported to interplay with SWI/SNF complex during cancer progression. However, whether the interaction between ARID1A and IncRNA affects hepatocellular carcinoma (HCC) still needs to be investigated. Here, we reveal that ARIDIA interacts with IncRNA MVIH through some region(s) or domain(s) including ARID domain and C-terminal ARIDIA protein binding domain. ARIDIA upregulates its downstream target CDKN1A and suppresses HCC cell proliferation and migration through inhibiting MVIH. Our data suggests that deficiency or loss of functional mutations of ARID1A in HCC cells might contribute to the increased activity of certain cancer-promoting IncRNAs. (C) 2017 Elsevier Inc. All rights reserved.
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