期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 33, 期 9, 页码 905-918出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2016.0303
关键词
HIV; AIDS; redox homeostasis; cytokines; glutathione
资金
- Western University of Health Sciences and Your Energy Systems
HIV infects and destroys CD4+ T cells leading to a compromised immune system. In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm(3) were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period. Baseline measurements in HIV-positive subjects show a significant decrease in levels of interleukin (IL)-12, IL-2, and interferon (IFN)-, along with a substantial increase in the levels of IL-6, IL-10, transforming growth factor (TGF)-, and free radicals, compared to healthy individuals. Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-, IL-1, and IL-17, compared to their placebo counterparts. Levels of free radicals in CD4+ T cells stabilized, while GSH levels increased in the treatment group. Those in the placebo group showed no significant difference throughout the study. In summary, supplementation with L-GSH in HIV-infected individuals with CD4+ T cell counts below 350 cells/mm(3) can help restore redox homeostasis and cytokine balance, therefore aiding the immune system to control opportunistic infections.
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