期刊
JACC-CARDIOVASCULAR IMAGING
卷 10, 期 9, 页码 1056-1071出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2017.07.001
关键词
cardiac imaging; clinical trials; HF; left ventricular remodeling
资金
- NHLBI NIH HHS [U01 HL117006] Funding Source: Medline
The need for noninvasive assessment of cardiac volumes and ejection fraction (EF) ushered in the use of cardiac imaging techniques in heart failure (HF) trials that investigated the roles of pharmacological and device-based therapies. However, in contrast to HF with reduced EF (HFrEF), modern HF pharmacotherapy has not improved outcomes in HF with preserved EF (HFpEF), largely attributed to patient heterogeneity and incomplete understanding of pathophysiological insights underlying the clinical presentations of HFpEF. Modern cardiac imaging methods offer insights into many sets of changes in cardiac tissue structure and function that can precisely link cause with cardiac remodeling at organ and tissue levels to clinical presentations in HF. This has inspired investigators to seek a more comprehensive understanding of HF presentations using imaging techniques. This article summarizes the available evidence regarding the role of cardiac imaging in HF. Furthermore, we discuss the value of cardiac imaging techniques in identifying HF patient subtypes who share similar causes and mechanistic pathways that can be targeted using specific HF therapies. (C) 2017 by the American College of Cardiology Foundation.
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