期刊
CELL HOST & MICROBE
卷 22, 期 3, 页码 269-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2017.08.013
关键词
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资金
- National Institute of Dental and Craniofacial Research of the National Institutes of Health [R01DE019665]
- Australian National Health and Medical Research Council [437015, 607358, 349448, 1006294]
- Bonnie Babes Foundation [BBF20704]
- Financial Markets Foundation for Children [032-2007, 223-2009]
- Victorian Government's Operational Infrastructure Support Program
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged 5-11. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors.
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