期刊
ADVANCED MATERIALS
卷 29, 期 34, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201701268
关键词
Bi2Se3 nanoparticles; immunity; radiation side-effects; selenocysteine; synergistic therapies
类别
资金
- National Basic Research Program of China [2016YFA0201600, 2014CB931900, 2015CB932104]
- National Natural Science Foundation of China [31571015, 11621505, 21320102003]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH022]
- Innovative Research Groups of the National Natural Science Foundation of China [11621505]
- National Science Fund for Distinguished Young Scholars [11425520]
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2Se3 nanoparicles (PVP-Bi2Se3@Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2Se3@Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2Se3@Sec NPs during the treatment, which demonstrates that PVP-Bi2Se3@Sec NPs have good biocompatibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据