期刊
CHEMOSPHERE
卷 185, 期 -, 页码 237-246出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2017.07.004
关键词
BPA; CYP19; Steroidogenesis; Sex hormone ratio; Leydig cell
资金
- Ministry of Science and Technology [NSC 102-2320-B-016-001-MY2, MOST 104-2320-B-016-015]
- Ministry of National Defense in Taiwan [MAB-104-090]
Bisphenol A (BPA) is a well-known endocrine disrupting chemical (EDC) that is used to manufacture plastic consumer products. It is well known that exposure to BPA can induce defects in gonad development and negatively influences reproductive function in both males and females. In this study, we assessed the effects of BPA on hormone production in Leydig cells, which secrete hormones in the testes and support male fertility. We examined two steroidogenic enzymes, CYP11A1 and CYP19 that involved in sex hormone synthesis in mouse MA-10 Leydig cells. We found that BPA activated CYP gene in both mRNA and protein levels then resulted in alteration of the normal sex hormone ratio. Furthermore, we found that BPA induced c-Jun phosphorylation and contributed to CYP gene expression. Similar results were observed in an animal study. In conclusion, BPA disrupts the hormone environment in testis via steroidogenic gene activation through the JNK/c-Jun signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved.
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