期刊
ARTHRITIS CARE & RESEARCH
卷 69, 期 5, 页码 649-658出版社
WILEY
DOI: 10.1002/acr.23005
关键词
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类别
资金
- European Union [607510]
- Merck Serono
- Bioclinica/Synarc
- Samumed
- Abbvie
- Kolon
- Synarc
- Ampio
- BICL
- Orthotrophix
- European Union [607510]
- Merck Serono
- Bioclinica/Synarc
- Samumed
- Abbvie
- Kolon
- Synarc
- Ampio
- BICL
- Orthotrophix
ObjectiveTo perform a systematic review and meta-analysis on the association between knee extensor strength and the risk of structural, symptomatic, or functional deterioration in individuals with or at risk of knee osteoarthritis (KOA). MethodsWe systematically identified and methodologically appraised all longitudinal studies (1-year followup) reporting an association between knee extensor strength and structural (tibiofemoral, patellofemoral), symptomatic (self-reported, knee replacement), or functional (subjective, objective) decline in individuals with or at risk of radiographic or symptomatic KOA. Results were pooled for each of the above associations using meta-analysis, or if necessary, summarized according to a best-evidence synthesis. ResultsFifteen studies were included, evaluating >8,000 participants (51% female), with a followup time between 1.5 and 8 years. Meta-analysis revealed that lower knee extensor strength was associated with an increased risk of symptomatic (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] pain: odds ratio [OR] 1.35, 95% confidence interval [95% CI] 1.10-1.67) and functional decline (WOMAC function: OR 1.38, 95% CI 1.00-1.89, and chair-stand task: OR 1.03, 95% CI 1.03-1.04), but not increased risk of radiographic tibiofemoral joint space narrowing (JSN) (OR 1.15, 95% CI 0.84-1.56). No trend in risk was observed for KOA status (present versus absent). Best-evidence synthesis showed inconclusive evidence for lower knee extensor strength being associated with increased risk of patellofemoral deterioration. ConclusionMeta-analysis showed that lower knee extensor strength is associated with an increased risk of symptomatic and functional deterioration, but not tibiofemoral JSN. The risk of patellofemoral deterioration in the presence of knee extensor strength deficits is inconclusive.
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