期刊
REGENERATIVE BIOMATERIALS
卷 4, 期 3, 页码 159-166出版社
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbx001
关键词
RGD peptide; graphene oxide; poly(lactic-co-glycolic acid); biofunctional scaffold; vascular smooth muscle cell
资金
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Korean government (MEST) [2015M3A9E2028643]
- Basic Science Research Program through the NRF of Korea - Ministry of Education [2016R1D1A1B03931076]
- National Research Foundation of Korea [2015M3A9E2028643, 2016R1D1A1B03931076] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In recent years, much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular behaviors. In our study, RGD peptide and graphene oxide (GO) co-functionalized poly(lactide-co-glycolide, PLGA) (RGD-GO-PLGA) nanofiber mats were fabricated via electrospinning, and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue engineering. Scanning electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of randomoriented electrospun nanofibers with average diameter of 558nm. The successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic analysis. Moreover, the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and GO. It was found that the mats were thermally stable under the cell culture condition. Furthermore, the initial attachment and proliferation of primarily cultured vascular smoothmuscle cells (VSMCs) on the RGD-GO-PLGA nanofibermats were evaluated. It was revealed that the RGD-GO-PLGA nanofibermats can effectively promote the growth of VSMCs. In conclusion, our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smoothmuscle.
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