期刊
ANNALS OF TRANSLATIONAL MEDICINE
卷 5, 期 11, 页码 -出版社
AME PUBL CO
DOI: 10.21037/atm.2017.04.29
关键词
Mesothelioma; BRCA-associated protein 1 (BAP1); asbestos; erionite; high mobility group box protein-1 (HMGB1); SV40
资金
- NCI [R01 CA198138]
- NCI-R01 [CA160715]
- University of Hawaii Foundation
- United-For-A-Cure Riviera Foundation
- CDMRP [917422, CA160715] Funding Source: Federal RePORTER
Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. These discoveries are: (I) the critical role of chronic inflammation in promoting mesothelioma growth, driven by the release of high mobility group box protein-1 (HMGB1) following asbestos deposition in tissues and its potential role as a biomarker to identify asbestos exposed individuals and mesothelioma patients; (II) the discovery that inherited heterozygous germline mutations of the deubiquitylase BRCA-associated protein 1 (BAP1) cause a high incidence of mesothelioma in some families; and that (III) germline BAP1 mutations lower the threshold of asbestos required to cause mesothelioma in mice, evidence of gene X environment interaction. These findings together with the identification of novel serum biomarkers, including HMGB1, Fibulin-3, etc., promise to revolutionize screening and treatment of this malignancy in the coming years.
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