期刊
DRUG DEVELOPMENT RESEARCH
卷 78, 期 6, 页码 283-291出版社
WILEY
DOI: 10.1002/ddr.21399
关键词
target drug delivery; doxorubicin; RGD; nanomedicine
资金
- National Natural Science Foundation of China [81503259]
- Jiangsu Natural Science Foundation of China [BK20151002]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PPZY2015A070]
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions [PPZY2015A070]
Doxorubicin (DOX) is commonly used for the treatment of breast cancer and lymphoma. However, its clinical use has been severely limited due to cardiotoxicity, requiring the development of safer and more efficient pharmaceutical formulations of DOX. Advances in nanotechnology have provided new ways to administer chemotherapeutic drugs like DOX are conveyed into the body and to tumor sites. These Nanotechnology approaches have aided in the selective accumulation of DOX into tumor sites via the enhanced permeability and retention. However, the absence of active targeting ligands still hinders the effective delivery of DOX. Among all active targeting ligands developed to date, RGD peptide (Arginylglycylaspartic acid) occupies a unique position owing to its inherent safety, biocompatibility, and targeting ability. Accordingly, modification of DOX with RGD ligand is anticipated to improve transport of DOX into tumor cells. In this review, we discuss using RGD peptide for improving the therapeutic efficacy of DOX nanomedicine. Drug Dev Res 78 : 283-291, 2017. (c) 2017 Wiley Periodicals, Inc.
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