期刊
VIRUSES-BASEL
卷 9, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v9010024
关键词
RNA quality control; gene expression; translation; RNA-protein interactions
类别
资金
- NCCR RNA & Disease - Swiss National Science Foundation (SNSF)
- SNFS [31003A-162986]
- Finnish Cancer Foundation, Finland
- Swiss National Science Foundation (SNF) [31003A_162986] Funding Source: Swiss National Science Foundation (SNF)
Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA((+) RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD.
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