期刊
VIRUSES-BASEL
卷 9, 期 11, 页码 -出版社
MDPI AG
DOI: 10.3390/v9110341
关键词
Epstein-Barr virus; DNA damage response; lytic reactivation
类别
资金
- Research Grant Council, Hong Kong: General Research Fund [106130105, 106160185, 106140069, 102120176]
- Area of Excellence [AoE/M-06/08]
- Theme-Based Research Scheme [T12-401/13-R]
- Collaborative Research Fund [C7027-16G]
- Health and Medical Research Fund of Hong Kong [260870784]
- Conference and Research Grant (CRCG), University of Hong Kong, Hong Kong
The Epstein-Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt's lymphoma, Hodgkin's lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. Intensive research has shown that EBV triggers a DNA damage response (DDR) during primary infection and lytic reactivation. The EBV-encoded viral proteins have been implicated in deregulating the DDR signaling pathways. The consequences of DDR inactivation lead to genomic instability and promote cellular transformation. This review summarizes the current understanding of the relationship between EBV infection and the DDR transducers, including ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3-related), and DNA-PK (DNA-dependent protein kinase), and discusses how EBV manipulates the DDR signaling pathways to complete the replication process of viral DNA during lytic reactivation.
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