期刊
VIRUSES-BASEL
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/v9070180
关键词
human papillomavirus; papillomaviruses; oncogenic virus; cancer; HPV E6; HPV E7; hTERT; telomerase
类别
资金
- NCI NIH HHS [R01 CA172742] Funding Source: Medline
Telomerase extends the repetitive DNA at the ends of linear chromosomes, and it is normally active in stem cells. When expressed in somatic diploid cells, it can lead to cellular immortalization. Human papillomaviruses (HPVs) are associated with and high-risk for cancer activate telomerase through the catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT). The expression of hTERT is affected by both high-risk HPVs, E6 and E7. Seminal studies over the last two decades have identified the transcriptional, epigenetic, and post-transcriptional roles high-risk E6 and E7 have in telomerase induction. This review will summarize these findings during infection and highlight the importance of telomerase activation as an oncogenic pathway in HPV-associated cancer development and progression.
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