期刊
VIRUSES-BASEL
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v9020031
关键词
African swine fever virus; outbreaks; Democratic Republic of Congo; swine; genotypes; molecular epidemiology; p72 gene; p54 gene; CVR
类别
资金
- International Atomic Energy Agency (IAEA) project Improvement of Veterinary Laboratory Capacities in Sub-Saharan African Countries
- Wellcome Trust (WT) [WT075813/C/04/Z, WT087546MA]
- BBSRC [BBS/E/I/00001714, BBS/E/I/00007035] Funding Source: UKRI
African swine fever (ASF) is a devastating disease of domestic pigs. It is a socioeconomically important disease, initially described from Kenya, but subsequently reported in most Sub-Saharan countries. ASF spread to Europe, South America and the Caribbean through multiple introductions which were initially eradicated-except for Sardinia-followed by re-introduction into Europe in 2007. In this study of ASF within the Democratic Republic of the Congo, 62 domestic pig samples, collected between 2005-2012, were examined for viral DNA and sequencing at multiple loci: C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein). Phylogenetic analyses identified three circulating genotypes: I (64.5% of samples), IX (32.3%), and XIV (3.2%). This is the first evidence of genotypes IX and XIV within this country. Examination of the CVR revealed high levels of intra-genotypic variation, with 19 identified variants.
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