期刊
VIRUSES-BASEL
卷 9, 期 11, 页码 -出版社
MDPI AG
DOI: 10.3390/v9110329
关键词
calicivirus; polymerase; structure; interaction; precursor
类别
资金
- National Research Foundation [NRF-2016R1E1A1A01942558]
- Ministry of Education [NRF-2015R1D1A1A01061027, NRF-2013R1A1A2064940]
Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the error-prone nature of RNA-dependent RNA polymerase (RdRp), this article focuses on recent studies of the structures and functions of RdRp from caliciviruses. It also provides recent advances in the interactions of RdRp with virion protein genome-linked (VPg) and RNA and the structural and functional features of its precursor.
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